Ontology highlight
ABSTRACT:
SUBMITTER: Galasiti Kankanamalage AC
PROVIDER: S-EPMC5501333 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Galasiti Kankanamalage Anushka C AC Kim Yunjeong Y Rathnayake Athri D AD Damalanka Vishnu C VC Weerawarna Pathum M PM Doyle Sean T ST Alsoudi Amer F AF Dissanayake D M Padmasankha DMP Lushington Gerald H GH Mehzabeen Nurjahan N Battaile Kevin P KP Lovell Scott S Chang Kyeong-Ok KO Groutas William C WC
European journal of medicinal chemistry 20161114
Human noroviruses are the primary cause of epidemic and sporadic acute gastroenteritis. The worldwide high morbidity and mortality associated with norovirus infections, particularly among the elderly, immunocompromised patients and children, constitute a serious public health concern. There are currently no approved human vaccines or norovirus-specific small-molecule therapeutics or prophylactics. Norovirus 3CL protease has recently emerged as a potential therapeutic target for the development o ...[more]