Ontology highlight
ABSTRACT:
SUBMITTER: Hu JK
PROVIDER: S-EPMC5501749 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Hu Jimmy Kuang-Hsien JK Du Wei W Shelton Samuel J SJ Oldham Michael C MC DiPersio C Michael CM Klein Ophir D OD
Cell stem cell 20170427 1
Tissue homeostasis requires the production of newly differentiated cells from resident adult stem cells. Central to this process is the expansion of undifferentiated intermediates known as transit-amplifying (TA) cells, but how stem cells are triggered to enter this proliferative TA state remains an important open question. Using the continuously growing mouse incisor as a model of stem cell-based tissue renewal, we found that the transcriptional cofactors YAP and TAZ are required both to mainta ...[more]