Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen K
PROVIDER: S-EPMC6279518 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Nguyen Khoa K Yan Yuanqing Y Yuan Bin B Dasgupta Abhishek A Sun Jeffrey J Mu Hong H Do Kim-Anh KA Ueno Naoto T NT Andreeff Michael M Battula V Lokesh VL
Molecular cancer therapeutics 20180920 12
Breast cancer stem-like cells (BCSC) are implicated in cancer recurrence and metastasis of triple-negative breast cancer (TNBC). We have recently discovered that ganglioside GD2 expression defines BCSCs and that ST8SIA1 regulates GD2 expression and BCSC function. In this report, we show that ST8SIA1 is highly expressed in primary TNBC; its expression is positively correlated with the expression of several BCSC-associated genes such as BCL11A, FOXC1, CXCR4, PDGFRβ, SOX2, and mutations in p53. CRI ...[more]