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10 Years of GWAS Discovery: Biology, Function, and Translation.

ABSTRACT: Application of the experimental design of genome-wide association studies (GWASs) is now 10 years old (young), and here we review the remarkable range of discoveries it has facilitated in population and complex-trait genetics, the biology of diseases, and translation toward new therapeutics. We predict the likely discoveries in the next 10 years, when GWASs will be based on millions of samples with array data imputed to a large fully sequenced reference panel and on hundreds of thousands of samples with whole-genome sequencing data.

SUBMITTER: Visscher PM

PROVIDER: S-EPMC5501872 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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10 Years of GWAS Discovery: Biology, Function, and Translation.

Visscher Peter M PM Wray Naomi R NR Zhang Qian Q Sklar Pamela P McCarthy Mark I MI Brown Matthew A MA Yang Jian J

American journal of human genetics 20170701 1

Application of the experimental design of genome-wide association studies (GWASs) is now 10 years old (young), and here we review the remarkable range of discoveries it has facilitated in population and complex-trait genetics, the biology of diseases, and translation toward new therapeutics. We predict the likely discoveries in the next 10 years, when GWASs will be based on millions of samples with array data imputed to a large fully sequenced reference panel and on hundreds of thousands of samp ...[more]

PMID: 28686856

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