Ontology highlight
ABSTRACT:
SUBMITTER: Khera AV
PROVIDER: S-EPMC5935119 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Khera Amit V AV Kathiresan Sekar S
Nature reviews. Genetics 20170313 6
Coronary artery disease is the leading global cause of mortality. Long recognized to be heritable, recent advances have started to unravel the genetic architecture of the disease. Common variant association studies have linked approximately 60 genetic loci to coronary risk. Large-scale gene sequencing efforts and functional studies have facilitated a better understanding of causal risk factors, elucidated underlying biology and informed the development of new therapeutics. Moving forwards, genet ...[more]