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Chemical and mechanical modulation of polymeric micelle assembly.

ABSTRACT: Recently, polymeric micelles self-assembled from amphiphilic polymers have been studied for various industrial and biomedical applications. This nanoparticle self-assembly typically occurs in a solvent-exchange process. In this process, the quality of the resulting particles is uncontrollably mediated by polymeric solubility and mixing conditions. Here, we hypothesized that improving the solubility of an amphiphilic polymer in an organic solvent via chemical modification while controlling the mixing rate of organic and aqueous phases would enhance control over particle morphology and size. We examined this hypothesis by synthesizing a poly(2-hydroxyethyl)aspartamide (PHEA) grafted with controlled numbers of octadecyl (C18) chains and oligovaline groups (termed "oligovaline-PHEA-C18"). The mixing rate of DMF and water was controlled either by microfluidic mixing of laminar DMF and water flows or through turbulent bulk mixing. Interestingly, oligovaline-PHEA-C18 exhibited an increased solubility in DMF compared with PHEA-C18, as demonstrated by an increase of mixing energy. In addition, increasing the mixing rate between water and DMF using the microfluidic mixer resulted in a decrease of the diameter of the resulting polymeric micelles, as compared with the particles formed from a bulk mixing process. Overall, these findings will expand the parameter space available to control particle self-assembly while also serving to improve existing nanoparticle processing techniques.

SUBMITTER: Clay NE

PROVIDER: S-EPMC5501961 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Chemical and mechanical modulation of polymeric micelle assembly.

Clay Nicholas E NE Whittenberg Joseph J JJ Leong Jiayu J Kumar Vivek V Chen Jinrong J Choi Insil I Liamas Evangelos E Schieferstein Jeremy M JM Jeong Jae Hyun JH Kim Dong Hyun DH Zhang Zhenyu Jason ZJ Kenis Paul J A PJA Kim Il Won IW Kong Hyunjoon H

Nanoscale 20170401 16

Recently, polymeric micelles self-assembled from amphiphilic polymers have been studied for various industrial and biomedical applications. This nanoparticle self-assembly typically occurs in a solvent-exchange process. In this process, the quality of the resulting particles is uncontrollably mediated by polymeric solubility and mixing conditions. Here, we hypothesized that improving the solubility of an amphiphilic polymer in an organic solvent via chemical modification while controlling the mi ...[more]

PMID: 28397883

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Chemical and mechanical modulation of polymeric micelle assembly.

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Chemical and mechanical modulation of polymeric micelle assembly.

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