Ontology highlight
ABSTRACT:
SUBMITTER: Russo MW
PROVIDER: S-EPMC5502673 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Russo Mark W MW Steuerwald Nury N Norton Harry J HJ Anderson William E WE Foureau David D Chalasani Naga N Fontana Robert J RJ Watkins Paul B PB Serrano Jose J Bonkovsky Herbert L HL
Liver international : official journal of the International Association for the Study of the Liver 20161129 5
<h4>Background & aims</h4>Drug induced liver injury (DILI) is challenging because of the lack of biomarkers to predict mortality. Our aim was to describe miRNA changes in sera of subjects with acute idiosyncratic DILI and determine if levels of miRNAs were associated with 6 month mortality.<h4>Methods</h4>Clinical data and sera were collected from subjects enrolled in the Drug Induced Liver Injury Network prospective study. miRNAs were isolated from serum obtained from 78 subjects within 2 weeks ...[more]