Ontology highlight
ABSTRACT:
SUBMITTER: Makino H
PROVIDER: S-EPMC5502752 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Makino Hiroshi H Ren Chi C Liu Haixin H Kim An Na AN Kondapaneni Neehar N Liu Xin X Kuzum Duygu D Komiyama Takaki T
Neuron 20170501 4
Learning involves a transformation of brain-wide operation dynamics. However, our understanding of learning-related changes in macroscopic dynamics is limited. Here, we monitored cortex-wide activity of the mouse brain using wide-field calcium imaging while the mouse learned a motor task over weeks. Over learning, the sequential activity across cortical modules became temporally more compressed, and its trial-by-trial variability decreased. Moreover, a new flow of activity emerged during learnin ...[more]