Ontology highlight
ABSTRACT:
SUBMITTER: Hwang EJ
PROVIDER: S-EPMC6821459 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Hwang Eun Jung EJ Dahlen Jeffrey E JE Hu Yvonne Yuling YY Aguilar Karina K Yu Bin B Mukundan Madan M Mitani Akinori A Komiyama Takaki T
Science advances 20191030 10
Motor learning involves reorganization of the primary motor cortex (M1). However, it remains unclear how the involvement of M1 in movement control changes during long-term learning. To address this, we trained mice in a forelimb-based motor task over months and performed optogenetic inactivation and two-photon calcium imaging in M1 during the long-term training. We found that M1 inactivation impaired the forelimb movements in the early and middle stages, but not in the late stage, indicating tha ...[more]