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Treatment of NRAS-mutated advanced or metastatic melanoma: rationale, current trials and evidence to date.

ABSTRACT: The disease course of BRAF (v-raf murine sarcoma viral oncogene homolog B1)-mutant melanoma has been drastically improved by the arrival of targeted therapies. NRAS (neuroblastoma RAS viral oncogene homolog)-mutated melanoma represents 15-25% of all metastatic melanoma patients. It currently does not have an approved targeted therapy. Metastatic patients receive immune-based therapies as first-line treatments, then cytotoxic chemotherapy like carboplatin/paclitaxel (C/P), dacarbazine (DTIC) or temozolomide (TMZ) as a second-line treatment. We will review current preclinical and clinical developments in NRAS-mutated melanoma, and analyze ongoing clinical trials that are evaluating the benefit of different targeted and immune-based therapies, either tested as single agents or in combination, in NRAS-mutant melanoma.

SUBMITTER: Boespflug A

PROVIDER: S-EPMC5502949 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Treatment of NRAS-mutated advanced or metastatic melanoma: rationale, current trials and evidence to date.

Boespflug Amélie A Caramel Julie J Dalle Stephane S Thomas Luc L

Therapeutic advances in medical oncology 20170529 7

The disease course of BRAF (v-raf murine sarcoma viral oncogene homolog B1)-mutant melanoma has been drastically improved by the arrival of targeted therapies. NRAS (neuroblastoma RAS viral oncogene homolog)-mutated melanoma represents 15-25% of all metastatic melanoma patients. It currently does not have an approved targeted therapy. Metastatic patients receive immune-based therapies as first-line treatments, then cytotoxic chemotherapy like carboplatin/paclitaxel (C/P), da ...[more]

PMID: 28717400

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