Ontology highlight
ABSTRACT:
SUBMITTER: Deng X
PROVIDER: S-EPMC5503593 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Deng Xinzhou X Tu Zhenbo Z Xiong Meng M Tembo Kingsley K Zhou Lu L Liu Pan P Pan Shan S Xiong Jie J Yang Xiangyong X Leng Jun J Zhang Qian Q Xiao Ruijing R Zhang Qiuping Q
Oncotarget 20170601 24
Adult T-cell acute lymphoblastic leukemia (T-ALL) is a refractory leukemia. We previously showed that CCL25/CCR9 promotes T-ALL metastasis. In the present study, we assessed the effects of CCL25 on Wnt expression and the effects of Wnt5a and CCL25 on PI3K/Akt and RhoA activation. Transwell assays and mouse xenograft experiments were utilized to assess the effects of Wnt5a and CCL25 on MOLT4 cell invasion, migration and metastasis. The effects of Wnt5a on MOLT4 cell actin polarization and pseudop ...[more]