Ontology highlight
ABSTRACT:
SUBMITTER: Wochal P
PROVIDER: S-EPMC5503690 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Wochal Paulina P Rathinam Vijay A K VA Dunne Aisling A Carlson Thaddeus T Kuang Wen W Seidl Katherine J KJ Hall J Perry JP Lin Lih-Ling LL Collins Mary M Schattgen Stefan A SA MacKay Christopher R CR Fagundes Caio T CT Carpenter Susan S Fitzgerald Katherine A KA O'Neill Luke A J LA
Journal of immunology (Baltimore, Md. : 1950) 20140711 4
TLR4 interactor with leucine-rich repeats (TRIL) is a brain-enriched accessory protein that is important in TLR3 and TLR4 signaling. In this study, we generated Tril(-/-) mice and examined TLR responses in vitro and in vivo. We found a role for TRIL in both TLR4 and TLR3 signaling in mixed glial cells, consistent with the high level of expression of TRIL in these cells. We also found that TRIL is a modulator of the innate immune response to LPS challenge and Escherichia coli infection in vivo. T ...[more]