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Intraoperative adjuncts for malignant pleural mesothelioma.


ABSTRACT: Malignant pleural mesothelioma (MPM) is a rapidly fatal disease. Multimodality surgically based therapies may extend survival in select patients, however, local relapse after resection is common. Novel intraoperative adjunctive therapies including heated intraoperative chemotherapy (HIOC), heated intraoperative povidone-iodine (PVP-I), and photodynamic therapy (PDT) target micrometastatic disease and aim to improve local control. This review details the most recent studies and trials of HIOC, heated intraoperative PVP-I, and PDT, this aims to provide an update on some of the most promising intraoperative adjuncts for patients with MPM.

SUBMITTER: Chan WH 

PROVIDER: S-EPMC5504117 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Intraoperative adjuncts for malignant pleural mesothelioma.

Chan Warren Ho WH   Sugarbaker David J DJ   Burt Bryan M BM  

Translational lung cancer research 20170601 3


Malignant pleural mesothelioma (MPM) is a rapidly fatal disease. Multimodality surgically based therapies may extend survival in select patients, however, local relapse after resection is common. Novel intraoperative adjunctive therapies including heated intraoperative chemotherapy (HIOC), heated intraoperative povidone-iodine (PVP-I), and photodynamic therapy (PDT) target micrometastatic disease and aim to improve local control. This review details the most recent studies and trials of HIOC, he  ...[more]

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