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Targeting the epigenome in malignant pleural mesothelioma.


ABSTRACT: Malignant pleural mesotheliomas (MPM) are notoriously refractory to conventional treatment modalities. Recent insights regarding epigenetic alterations in MPM provide the preclinical rationale for the evaluation of novel combinatorial regimens targeting the epigenome in these neoplasms.

SUBMITTER: McLoughlin KC 

PROVIDER: S-EPMC5504118 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Targeting the epigenome in malignant pleural mesothelioma.

McLoughlin Kaitlin C KC   Kaufman Andrew S AS   Schrump David S DS  

Translational lung cancer research 20170601 3


Malignant pleural mesotheliomas (MPM) are notoriously refractory to conventional treatment modalities. Recent insights regarding epigenetic alterations in MPM provide the preclinical rationale for the evaluation of novel combinatorial regimens targeting the epigenome in these neoplasms. ...[more]

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