Ontology highlight
ABSTRACT:
SUBMITTER: Yoshioka Y
PROVIDER: S-EPMC5504314 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Yoshioka Yuichiro Y Suzuki Takehiro T Matsuo Yo Y Tsurita Giichiro G Watanabe Toshiaki T Dohmae Naoshi N Nakamura Yusuke Y Hamamoto Ryuji R
Cancer medicine 20170622 7
HER2 is a receptor tyrosine kinase, which is amplified and overexpressed in a subset of human cancers including breast and gastric cancers, and is indicated in its involvement in progression of cancer. Although its specific ligand(s) has not been detected, HER2 homodimerization, which is critical for its activation, is considered to be dependent on its expression levels. Here, we demonstrate a significant role of HER2 methylation by protein lysine methyltransferase SMYD3 in HER2 homodimerization ...[more]