Ontology highlight
ABSTRACT:
SUBMITTER: Garzia A
PROVIDER: S-EPMC5504347 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Garzia Aitor A Jafarnejad Seyed Mehdi SM Meyer Cindy C Chapat Clément C Gogakos Tasos T Morozov Pavel P Amiri Mehdi M Shapiro Maayan M Molina Henrik H Tuschl Thomas T Sonenberg Nahum N
Nature communications 20170707
Cryptic polyadenylation within coding sequences (CDS) triggers ribosome-associated quality control (RQC), followed by degradation of the aberrant mRNA and polypeptide, ribosome disassembly and recycling. Although ribosomal subunit dissociation and nascent peptide degradation are well-understood, the molecular sensors of aberrant mRNAs and their mechanism of action remain unknown. We studied the Zinc Finger Protein 598 (ZNF598) using PAR-CLIP and revealed that it cross-links to tRNAs, mRNAs and r ...[more]