Ontology highlight
ABSTRACT:
SUBMITTER: Roy AL
PROVIDER: S-EPMC5504908 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Trends in molecular medicine 20170428 6
The biochemical properties of the signal-induced multifunctional transcription factor II-I (TFII-I) indicate that it is involved in a variety of gene regulatory processes. Although gene ablation in murine models and cell-based assays show that it is encoded by an essential gene, GTF2I/Gtf2i, its physiologic role in human disorders was relatively unknown until recently. Novel studies show that it is involved in an array of human diseases including neurocognitive disorders, systemic lupus erythema ...[more]