Ribosomopathies: Old Concepts, New Controversies.
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ABSTRACT:
SUBMITTER: Farley-Barnes KI
PROVIDER: S-EPMC6852887 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Ribosomopathies: Old Concepts, New Controversies.
Farley-Barnes Katherine I KI Ogawa Lisa M LM Baserga Susan J SJ
Trends in genetics : TIG 20190731 10
Ribosomopathies are a diverse subset of diseases caused by reduced expression of, or mutations in, factors necessary for making ribosomes, the protein translation machinery in the cell. Despite the ubiquitous need for ribosomes in all cell types, ribosomopathies manifest with tissue-specific defects and sometimes increased cancer susceptibility, but few treatments target the underlying cause. By highlighting new research in the field, we review current hypotheses for the basis of this tissue spe ...[more]
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