Ontology highlight
ABSTRACT:
SUBMITTER: Durgan J
PROVIDER: S-EPMC5505699 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Durgan Joanne J Tseng Yun-Yu YY Hamann Jens C JC Domart Marie-Charlotte MC Collinson Lucy L Hall Alan A Overholtzer Michael M Florey Oliver O
eLife 20170711
Entosis is a form of epithelial cell cannibalism that is prevalent in human cancer, typically triggered by loss of matrix adhesion. Here, we report an alternative mechanism for entosis in human epithelial cells, driven by mitosis. Mitotic entosis is regulated by Cdc42, which controls mitotic morphology. Cdc42 depletion enhances mitotic deadhesion and rounding, and these biophysical changes, which depend on RhoA activation and are phenocopied by Rap1 inhibition, permit subsequent entosis. Mitotic ...[more]