Ontology highlight
ABSTRACT:
SUBMITTER: Xiao Z
PROVIDER: S-EPMC5505988 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Xiao Ziwei Z Ye Zhiyong Z Tadwal Vikeramjeet Singh VS Shen Meixin M Ren Ee Chee EC
Scientific reports 20170711 1
Host CD8 T cell response to viral infections involves recognition of 8-10-mer peptides presented by MHC-I molecules. However, proteasomes generate predominantly 2-7-mer peptides, but the role of these peptides is largely unknown. Here, we show that single short peptides of <8-mer from Latent Membrane Protein 2 (LMP2) of Epstein Barr Virus (EBV) can bind HLA-A*11:01 and stimulate CD8<sup>+</sup> cells. Surprisingly, two peptide fragments between 4-7-mer derived from LMP2<sub>(340-349)</sub> were ...[more]