Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC5506005 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Xu Jian J Wang Ju-Xian JX Zhou Jin-Ming JM Xu Chang-Liang CL Huang Bin B Xing Yun Y Wang Bin B Luo Rui R Wang Yu-Cheng YC You Xue-Fu XF Lu Yu Y Yu Li-Yan LY
Scientific reports 20170711 1
Protein kinase B (PknB) is one of the Mycobacterium tuberculosis serine/threonine protein kinases and has an essential role in sustaining mycobacterial growth. Here, we identified and characterized a novel small molecule compound named IMB-YH-8 that inhibited PknB and served as anti-mycobacteria lead compound. IMB-YH-8 inhibited PknB auto-phosphorylation and the phosphorylation of GarA by PknB in a dose-dependent manner. The compound did not inhibit human Akt1 or other serine/threonine kinases i ...[more]