Ontology highlight
ABSTRACT:
SUBMITTER: Morettin A
PROVIDER: S-EPMC5506013 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Morettin Alan A Paris Geneviève G Bouzid Younes Y Baldwin R Mitchell RM Falls Theresa J TJ Bell John C JC Côté Jocelyn J
Scientific reports 20170711 1
Tudor domain containing protein 3 (TDRD3) is a modular protein identified based on its ability to recognize methylated arginine motifs through its Tudor domain. We have previously shown that TDRD3 localizes to cytoplasmic stress granules, a structure shown to promote survival upon treatment with chemotherapeutic drugs in cancer cells. Here, we report TDRD3 as a novel regulator of cell proliferation and invasion in breast cancer cells. Our study also demonstrates that TDRD3 depletion inhibits tum ...[more]