Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC5506049 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Zhang Shuo S Pan Chenyu C Lv Xiangdong X Wu Wei W Chen Hao H Wu Wenqing W Wu Hailong H Zhang Lei L Zhao Yun Y
Scientific reports 20170711 1
Hox genes play a fundamental role in regulating animal development. However, less is known about their functions on homeostasis maintenance in adult stem cells. Here, we report that the repression of an important axial Hox gene, Abdominal-B (Abd-B), in cyst stem cells (CySCs) is essential for the homeostasis and cell identity maintenance in the adult Drosophila testis. Derepression of Abd-B in CySCs disrupts the proper self-renewal of both germline stem cells (GSCs) and CySCs, and leads to an ex ...[more]