Ontology highlight
ABSTRACT:
SUBMITTER: Yuan F
PROVIDER: S-EPMC5506443 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Yuan Fuwen F Zhang Yu Y Ma Liwei L Cheng Qian Q Li Guodong G Tong Tanjun T
Aging cell 20170510 4
The nucleolus is a key organelle that is responsible for the synthesis of rRNA and assembly of ribosomal subunits, which is also the center of metabolic control because of the critical role of ribosomes in protein synthesis. Perturbations of rRNA biogenesis are closely related to cell senescence and tumor progression; however, the underlying molecular mechanisms are not well understood. Here, we report that cellular senescence-inhibited gene (CSIG) knockdown up-regulated NOLC1 by stabilizing the ...[more]