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RNA-binding proteins: modular design for efficient function.

ABSTRACT: Many RNA-binding proteins have modular structures and are composed of multiple repeats of just a few basic domains that are arranged in various ways to satisfy their diverse functional requirements. Recent studies have investigated how different modules cooperate in regulating the RNA-binding specificity and the biological activity of these proteins. They have also investigated how multiple modules cooperate with enzymatic domains to regulate the catalytic activity of enzymes that act on RNA. These studies have shown how, for many RNA-binding proteins, multiple modules define the fundamental structural unit that is responsible for biological function.

SUBMITTER: Lunde BM

PROVIDER: S-EPMC5507177 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature

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RNA-binding proteins: modular design for efficient function.

Lunde Bradley M BM Moore Claire C Varani Gabriele G

Nature reviews. Molecular cell biology 20070601 6

Many RNA-binding proteins have modular structures and are composed of multiple repeats of just a few basic domains that are arranged in various ways to satisfy their diverse functional requirements. Recent studies have investigated how different modules cooperate in regulating the RNA-binding specificity and the biological activity of these proteins. They have also investigated how multiple modules cooperate with enzymatic domains to regulate the catalytic activity of enzymes that act on RNA. Th ...[more]

PMID: 17473849

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