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Pentatricopeptide repeats: modular blocks for building RNA-binding proteins.

ABSTRACT: Pentatricopeptide repeat (PPR) proteins control diverse aspects of RNA metabolism across the eukaryotic domain. Recent computational and structural studies have provided new insights into how they recognize RNA, and show that the recognition is sequence-specific and modular. The modular code for RNA-binding by PPR proteins holds great promise for the engineering of new tools to target RNA and identifying RNAs bound by natural PPR proteins.

SUBMITTER: Filipovska A

PROVIDER: S-EPMC3858425 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Pentatricopeptide repeats: modular blocks for building RNA-binding proteins.

Filipovska Aleksandra A Rackham Oliver O

RNA biology 20130423 9

Pentatricopeptide repeat (PPR) proteins control diverse aspects of RNA metabolism across the eukaryotic domain. Recent computational and structural studies have provided new insights into how they recognize RNA, and show that the recognition is sequence-specific and modular. The modular code for RNA-binding by PPR proteins holds great promise for the engineering of new tools to target RNA and identifying RNAs bound by natural PPR proteins. ...[more]

PMID: 23635770

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