Ontology highlight
ABSTRACT:
SUBMITTER: Bodine TJ
PROVIDER: S-EPMC5507437 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Bodine Truston J TJ Evangelista Michael A MA Chang Huan Ting HT Ayoub Christopher A CA Samuel Buck S BS Sucgang Richard R Zechiedrich Lynn L
PloS one 20170711 7
Escherichia coli encodes two DNA ligases, ligase A, which is essential under normal laboratory growth conditions, and ligase B, which is not. Here we report potential functions of ligase B. We found that across the entire Enterobacteriaceae family, ligase B is highly conserved in both amino acid identity and synteny with genes associated with oxidative stress. Deletion of ligB sensitized E. coli to specific DNA damaging agents and antibiotics resulted in a weak mutator phenotype, and decreased b ...[more]