Ontology highlight
ABSTRACT:
SUBMITTER: Seco-Cervera M
PROVIDER: S-EPMC5507909 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Seco-Cervera M M González-Rodríguez D D Ibáñez-Cabellos J S JS Peiró-Chova L L González-Cabo P P García-López E E Vílchez J J JJ Sanz-Gallego I I Pallardó F V FV García-Giménez J L JL
Scientific reports 20170712 1
MicroRNAs (miRNAs) are noncoding RNAs that contribute to gene expression modulation by regulating important cellular pathways. In this study, we used small RNA sequencing to identify a series of circulating miRNAs in blood samples taken from Friedreich's ataxia patients. We were thus able to develop a miRNA biomarker signature to differentiate Friedreich's ataxia (FRDA) patients from healthy people. Most research on FDRA has focused on understanding the role of frataxin in the mitochondria, and ...[more]