Ontology highlight
ABSTRACT:
SUBMITTER: Seco-Cervera M
PROVIDER: S-EPMC5839159 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Seco-Cervera Marta M González-Rodríguez Dayme D Ibáñez-Cabellos José Santiago JS Peiró-Chova Lorena L Pallardó Federico V FV García-Giménez José Luis JL
Scientific data 20180306
Friedreich's ataxia (FRDA; OMIM 229300), an autosomal recessive neurodegenerative mitochondrial disease, is the most prevalent hereditary ataxia. In addition, FRDA patients have shown additional non-neurological features such as scoliosis, diabetes, and cardiac complications. Hypertrophic cardiomyopathy, which is found in two thirds of patients at the time of diagnosis, is the primary cause of death in these patients. Here, we used small RNA-seq of microRNAs (miRNAs) purified from plasma samples ...[more]