Ontology highlight
ABSTRACT:
SUBMITTER: Shah AV
PROVIDER: S-EPMC5508205 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Shah A V AV Birdsey G M GM Peghaire C C Pitulescu M E ME Dufton N P NP Yang Y Y Weinberg I I Osuna Almagro L L Payne L L Mason J C JC Gerhardt H H Adams R H RH Randi A M AM
Nature communications 20170711
Notch and Angiopoietin-1 (Ang1)/Tie2 pathways are crucial for vascular maturation and stability. Here we identify the transcription factor ERG as a key regulator of endothelial Notch signalling. We show that ERG controls the balance between Notch ligands by driving Delta-like ligand 4 (Dll4) while repressing Jagged1 (Jag1) expression. In vivo, this regulation occurs selectively in the maturing plexus of the mouse developing retina, where Ang1/Tie2 signalling is active. We find that ERG mediates ...[more]