Ontology highlight
ABSTRACT:
SUBMITTER: Dufton NP
PROVIDER: S-EPMC5638819 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Dufton Neil P NP Peghaire Claire R CR Osuna-Almagro Lourdes L Raimondi Claudio C Kalna Viktoria V Chauhan Abhishek A Webb Gwilym G Yang Youwen Y Birdsey Graeme M GM Lalor Patricia P Mason Justin C JC Adams David H DH Randi Anna M AM
Nature communications 20171012 1
The role of the endothelium in protecting from chronic liver disease and TGFβ-mediated fibrosis remains unclear. Here we describe how the endothelial transcription factor ETS-related gene (ERG) promotes liver homoeostasis by controlling canonical TGFβ-SMAD signalling, driving the SMAD1 pathway while repressing SMAD3 activity. Molecular analysis shows that ERG binds to SMAD3, restricting its access to DNA. Ablation of ERG expression results in endothelial-to-mesenchymal transition (EndMT) and spo ...[more]