Ontology highlight
ABSTRACT:
SUBMITTER: Chan H
PROVIDER: S-EPMC5508521 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Annual review of biophysics 20170315
Telomerase is an RNA-protein complex that extends the 3' ends of linear chromosomes, using a unique telomerase reverse transcriptase (TERT) and template in the telomerase RNA (TR), thereby helping to maintain genome integrity. TR assembles with TERT and species-specific proteins, and telomerase function in vivo requires interaction with telomere-associated proteins. Over the past two decades, structures of domains of TR and TERT as well as other telomerase- and telomere-interacting proteins have ...[more]