Ontology highlight
ABSTRACT:
SUBMITTER: Passos DO
PROVIDER: S-EPMC5508583 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Passos Dario Oliveira DO Li Min M Yang Renbin R Rebensburg Stephanie V SV Ghirlando Rodolfo R Jeon Youngmin Y Shkriabai Nikoloz N Kvaratskhelia Mamuka M Craigie Robert R Lyumkis Dmitry D
Science (New York, N.Y.) 20170101 6320
Like all retroviruses, HIV-1 irreversibly inserts a viral DNA (vDNA) copy of its RNA genome into host target DNA (tDNA). The intasome, a higher-order nucleoprotein complex composed of viral integrase (IN) and the ends of linear vDNA, mediates integration. Productive integration into host chromatin results in the formation of the strand transfer complex (STC) containing catalytically joined vDNA and tDNA. HIV-1 intasomes have been refractory to high-resolution structural studies. We used a solubl ...[more]