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Hepatitis E Virus-Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing.


ABSTRACT: Hepatitis E virus (HEV) infection uncommonly causes chronic hepatitis and neurologic disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by metagenomic next-generation sequencing, illustrating the power of an unbiased molecular approach to microbial testing and the first reported case of HEV infection presumably acquired through lung transplantation.

SUBMITTER: Murkey JA 

PROVIDER: S-EPMC5508774 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Hepatitis E Virus-Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing.

Murkey Jamie A JA   Chew Kara W KW   Carlson Margrit M   Shannon Chelsea L CL   Sirohi Deepika D   Sample Hannah A HA   Wilson Michael R MR   Vespa Paul P   Humphries Romney M RM   Miller Steve S   Klausner Jeffrey D JD   Chiu Charles Y CY  

Open forum infectious diseases 20170613 3


Hepatitis E virus (HEV) infection uncommonly causes chronic hepatitis and neurologic disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by metagenomic next-generation sequencing, illustrating the power of an unbiased molecular approach to microbial testing and the first reported case of HEV infection presumably acquired through lung transplantation. ...[more]

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