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Hepatitis E Virus-Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing.

ABSTRACT: Hepatitis E virus (HEV) infection uncommonly causes chronic hepatitis and neurologic disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by metagenomic next-generation sequencing, illustrating the power of an unbiased molecular approach to microbial testing and the first reported case of HEV infection presumably acquired through lung transplantation.

SUBMITTER: Murkey JA

PROVIDER: S-EPMC5508774 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Hepatitis E Virus-Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing.

Murkey Jamie A JA Chew Kara W KW Carlson Margrit M Shannon Chelsea L CL Sirohi Deepika D Sample Hannah A HA Wilson Michael R MR Vespa Paul P Humphries Romney M RM Miller Steve S Klausner Jeffrey D JD Chiu Charles Y CY

Open forum infectious diseases 20170613 3

Hepatitis E virus (HEV) infection uncommonly causes chronic hepatitis and neurologic disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by metagenomic next-generation sequencing, illustrating the power of an unbiased molecular approach to microbial testing and the first reported case of HEV infection presumably acquired through lung transplantation. ...[more]

PMID: 28721353

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