Dataset Information

Building an experimental model of the human body with non-physiological parameters.

ABSTRACT: New advances in engineering and biomedical technology have enabled recent efforts to capture essential aspects of human physiology in microscale, in-vitro systems. The application of these advances to experimentally model complex processes in an integrated platform - commonly called a 'human-on-a-chip (HOC)' - requires that relevant compartments and parameters be sized correctly relative to each other and to the system as a whole. Empirical observation, theoretical treatments of resource distribution systems and natural experiments can all be used to inform rational design of such a system, but technical and fundamental challenges (e.g. small system blood volumes and context-dependent cell metabolism, respectively) pose substantial, unaddressed obstacles. Here, we put forth two fundamental principles for HOC design: inducing in-vivo-like cellular metabolic rates is necessary and may be accomplished in-vitro by limiting O2 availability and that the effects of increased blood volumes on drug concentration can be mitigated through pharmacokinetics-based treatments of solute distribution. Combining these principles with natural observation and engineering workarounds, we derive a complete set of design criteria for a practically realizable, physiologically faithful, five-organ millionth-scale (× 10-6) microfluidic model of the human body.

SUBMITTER: Labuz JM

PROVIDER: S-EPMC5509033 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Building an experimental model of the human body with non-physiological parameters.

Labuz Joseph M JM Moraes Christopher C Mertz David R DR Leung Brendan M BM Takayama Shuichi S

Technology 20170331 1

New advances in engineering and biomedical technology have enabled recent efforts to capture essential aspects of human physiology in microscale, <i>in-vitro</i> systems. The application of these advances to experimentally model complex processes in an integrated platform - commonly called a 'human-on-a-chip (HOC)' - requires that relevant compartments and parameters be sized correctly relative to each other and to the system as a whole. Empirical observation, theoretical treatments of resource ...[more]

PMID: 28713851

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Dataset Information

Building an experimental model of the human body with non-physiological parameters.

Publications

Building an experimental model of the human body with non-physiological parameters.

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