Mexneurin is a novel precursor of peptides in the central nervous system of rodents.
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ABSTRACT:
SUBMITTER: Matus-Ortega ME
PROVIDER: S-EPMC5509056 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
Mexneurin is a novel precursor of peptides in the central nervous system of rodents.
Matus-Ortega Maura E ME Leff Gelman Philippe P Calva-Nieves Juan C JC Flores-Zamora Anabel A Salazar-Juárez Alberto A Torner-Aguilar Carlos-Alejandro CA Gamba Gerardo G De Los Heros Paola P Peng Bonnie B Pintar John E JE Gompf Heinrich S HS Allen Charles N CN Antón-Palma Benito B
FEBS letters 20170601 12
Endomorphins (EMs) have been proposed as the endogenous ligand agonists of the μ-opioid receptor; however, no propeptide precursor protein for EMs has been identified. Here, to identify the presumed precursor of EMs, we designed an immunoscreening assay using specific affinity-purified rabbit antisera raised against synthetic EMs in a whole-mouse brain cDNA library. Following this approach, we identify a DNA sequence encoding a protein precursor, which we name proMexneurin, that contains three d ...[more]
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