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Anti-TNF-alpha agents and endothelial function in rheumatoid arthritis: a systematic review and meta-analysis.


ABSTRACT: Rheumatoid arthritis (RA) has been associated with endothelial dysfunction, a pathophysiological feature of atherosclerosis. Our aim was to determine whether TNF-? blockade has a beneficial effect on endothelial function in RA. We performed a systematic review with meta-analysis to evaluate the effect of anti-TNF-? agents on endothelial function in RA patients. MedLine, Cochrane CENTRAL and SCOPUS were searched up to March 2016. Inclusion criteria were: 1) randomised controlled trial (RCT), quasi-RCT, before-after cohort study; 2) including RA patients; 3) treatment with anti-TNF-? medications; 4) evaluating the change from baseline in endothelial function. The search strategy retrieved 180 records, of which 20 studies were included in the systematic review. Pooled analysis using a random-effects model demonstrated a significant improvement in endothelial function following anti-TNF-? treatment (SDM 0.987, 95%CI [0.64-1.33], p?

SUBMITTER: Ursini F 

PROVIDER: S-EPMC5509678 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Anti-TNF-alpha agents and endothelial function in rheumatoid arthritis: a systematic review and meta-analysis.

Ursini Francesco F   Leporini Christian C   Bene Fabiola F   D'Angelo Salvatore S   Mauro Daniele D   Russo Emilio E   De Sarro Giovambattista G   Olivieri Ignazio I   Pitzalis Costantino C   Lewis Myles M   Grembiale Rosa Daniela RD  

Scientific reports 20170713 1


Rheumatoid arthritis (RA) has been associated with endothelial dysfunction, a pathophysiological feature of atherosclerosis. Our aim was to determine whether TNF-α blockade has a beneficial effect on endothelial function in RA. We performed a systematic review with meta-analysis to evaluate the effect of anti-TNF-α agents on endothelial function in RA patients. MedLine, Cochrane CENTRAL and SCOPUS were searched up to March 2016. Inclusion criteria were: 1) randomised controlled trial (RCT), quas  ...[more]

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