Modulation of Interleukin-12 activity in the presence of heparin.
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ABSTRACT:
SUBMITTER: Jayanthi S
PROVIDER: S-EPMC5509706 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
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Modulation of Interleukin-12 activity in the presence of heparin.
Jayanthi Srinivas S Koppolu Bhanu Prasanth BP Nguyen Khue G KG Smith Sean G SG Felber Barbara K BK Kumar Thallapuranam Krishnaswamy Suresh TKS Zaharoff David A DA
Scientific reports 20170713 1
Glycosaminoglycans (GAGs), especially heparin and heparan sulfate (HS), modulate the functions of numerous cytokines. The aims of this multidisciplinary research were to characterize heparin binding to interleukin-12 (IL-12) and determine the mechanism(s) by which heparin influences IL-12 bioactivity. Heparin and HS were found to bind human IL-12 (hIL-12) with low micromolar affinity and increase hIL-12 bioactivity by more than 6-fold. Conversely, other GAGs did not demonstrate significant bindi ...[more]
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