Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.
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ABSTRACT:
SUBMITTER: Willems SM
PROVIDER: S-EPMC5510175 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.
Willems Sara M SM Wright Daniel J DJ Day Felix R FR Trajanoska Katerina K Joshi Peter K PK Morris John A JA Matteini Amy M AM Garton Fleur C FC Grarup Niels N Oskolkov Nikolay N Thalamuthu Anbupalam A Mangino Massimo M Liu Jun J Demirkan Ayse A Lek Monkol M Xu Liwen L Wang Guan G Oldmeadow Christopher C Gaulton Kyle J KJ Lotta Luca A LA Miyamoto-Mikami Eri E Rivas Manuel A MA White Tom T Loh Po-Ru PR Aadahl Mette M Amin Najaf N Attia John R JR Austin Krista K Benyamin Beben B Brage Søren S Cheng Yu-Ching YC Cięszczyk Paweł P Derave Wim W Eriksson Karl-Fredrik KF Eynon Nir N Linneberg Allan A Lucia Alejandro A Massidda Myosotis M Mitchell Braxton D BD Miyachi Motohiko M Murakami Haruka H Padmanabhan Sandosh S Pandey Ashutosh A Papadimitriou Ioannis I Rajpal Deepak K DK Sale Craig C Schnurr Theresia M TM Sessa Francesco F Shrine Nick N Tobin Martin D MD Varley Ian I Wain Louise V LV Wray Naomi R NR Lindgren Cecilia M CM MacArthur Daniel G DG Waterworth Dawn M DM McCarthy Mark I MI Pedersen Oluf O Khaw Kay-Tee KT Kiel Douglas P DP Pitsiladis Yannis Y Fuku Noriyuki N Franks Paul W PW North Kathryn N KN van Duijn Cornelia M CM Mather Karen A KA Hansen Torben T Hansson Ola O Spector Tim T Murabito Joanne M JM Richards J Brent JB Rivadeneira Fernando F Langenberg Claudia C Perry John R B JRB Wareham Nick J NJ Scott Robert A RA
Nature communications 20170712
Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P<5 × 10<sup>-8</sup>) in combined analyses. A number of these loci contain genes implicated in structure and function of skeletal m ...[more]
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