Dataset Information

Efficacy and Tolerability of Gabapentin in Adults with Sleep Disturbance in Medical Illness: A Systematic Review and Meta-analysis.

ABSTRACT:

Background and purpose

The aim of this study was to systematically review the efficacy and tolerability of gabapentin in the treatment of sleep disturbance in patients with medical illness.

Methods

PubMed was searched for randomized, double-blinded, placebo-controlled trials that reported sleep changes during gabapentin treatment up to November 2015.

Findings

This review included 26 studies involving 4,684 participants. Except for Composite Endpoint 3 [standardized mean difference (SMD)?=?0.09, 95% confidence interval (CI): -0.05-0.22] compared with the placebo group, the gabapentin group showed superior outcomes on our endpoints: Composite Endpoint 1 (SMD?=?0.50, 95% CI: 0.28-0.71), Composite Endpoint 2 (SMD?=?-0.53, 95% CI: -0.77 to -0.30), Composite Endpoint 4 (SMD?=?-0.38, 95% CI: -0.58 to -0.19), Composite Endpoint 5 [risk ratio (RR)?=?1.79, 95% CI: 1.24-2.58], and Composite Endpoint 6 (RR?=?0.48, 95% CI: 0.32-0.72). However, the patients in the gabapentin group showed worse tolerance than those in the placebo group (RR?=?1.38, 95% CI: 1.08-1.76).

Implications

This study is the first to systematically assess the clinical value of gabapentin for the treatment of sleep disorders. We found that regardless the type of sleep outcomes, gabapentin displayed stable treatment efficacy for sleep disturbance in patients with medical illness. However, when an average dose of approximately 1,800?mg/day was used, the risk of treatment discontinuation or drug withdrawal was relatively high. We recommend that further studies confirm these findings in patients with primary sleep disorders.

SUBMITTER: Liu GJ

PROVIDER: S-EPMC5510619 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Efficacy and Tolerability of Gabapentin in Adults with Sleep Disturbance in Medical Illness: A Systematic Review and Meta-analysis.

Liu Guang Jian GJ Karim Md Rezaul MR Xu Li Li LL Wang Song Lin SL Yang Chao C Ding Li L Wang Yun-Fu YF

Frontiers in neurology 20170714

<h4>Background and purpose</h4>The aim of this study was to systematically review the efficacy and tolerability of gabapentin in the treatment of sleep disturbance in patients with medical illness.<h4>Methods</h4>PubMed was searched for randomized, double-blinded, placebo-controlled trials that reported sleep changes during gabapentin treatment up to November 2015.<h4>Findings</h4>This review included 26 studies involving 4,684 participants. Except for Composite Endpoint 3 [standardized mean dif ...[more]

PMID: 28769860

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Dataset Information

Efficacy and Tolerability of Gabapentin in Adults with Sleep Disturbance in Medical Illness: A Systematic Review and Meta-analysis.

Background and purpose

Methods

Findings

Implications

Publications

Efficacy and Tolerability of Gabapentin in Adults with Sleep Disturbance in Medical Illness: A Systematic Review and Meta-analysis.

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