Synthetic and Computational Studies on the Rhodium-Catalyzed Hydroamination of Aminoalkenes.

ABSTRACT: The influence of ligand structure on rhodium-catalyzed hydroamination has been evaluated for a series of phosphinoarene ligands. These catalysts have been evaluated in a set of catalytic intramolecular Markovnikov hydroamination reactions. The mechanism of hydroamination catalyzed by the rhodium(I) complexes in this study was examined computationally, and the turnover-limiting step was elucidated. These computational studies were extended to a series of theoretical hydroamination catalysts to compare the electronic effects of the ancillary ligand substituents. The relative energies of intermediates and transition states were compared to those of intermediates in the reaction catalyzed by the unsubstituted catalyst. The experimental difference in the reactivities of electron-rich and electr

SUBMITTER: Strom AE 

PROVIDER: S-EPMC5510900 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature