Ontology highlight
ABSTRACT:
SUBMITTER: Zagni C
PROVIDER: S-EPMC5511049 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Zagni Chiara C Almeida Luciana O LO Balan Tarek T Martins Marco T MT Rosselli-Murai Luciana K LK Papagerakis Petros P Castilho Rogerio M RM Squarize Cristiane H CH
Stem cell reports 20170608 1
Tissue integrity requires constant maintenance of a quiescent, yet responsive, population of stem cells. In the skin, hair follicle stem cells (HFSCs) that reside within the bulge maintain tissue homeostasis in response to activating cues that occur with each new hair cycle or upon injury. We found that PTEN, a major regulator of the PI3K-AKT pathway, controlled HFSC number and size in the bulge and maintained genomically stable pluripotent cells. This regulatory function is central for HFSC qui ...[more]