Ontology highlight
ABSTRACT:
SUBMITTER: Vettiger A
PROVIDER: S-EPMC5511345 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Vettiger Andrea A Winter Julius J Lin Lin L Basler Marek M
Nature communications 20170713
The bacterial Type VI secretion system (T6SS) delivers proteins into target cells using fast contraction of a long sheath anchored to the cell envelope and wrapped around an inner Hcp tube associated with the secreted proteins. Mechanisms of sheath assembly and length regulation are unclear. Here we study these processes using spheroplasts formed from ampicillin-treated Vibrio cholerae. We show that spheroplasts secrete Hcp and deliver T6SS substrates into neighbouring cells. Imaging of sheath d ...[more]