Ontology highlight
ABSTRACT:
SUBMITTER: Kormos CM
PROVIDER: S-EPMC5512122 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Kormos Chad M CM Ondachi Pauline W PW Runyon Scott P SP Thomas James B JB Mascarella S Wayne SW Decker Ann M AM Navarro Hernán A HA Carroll F Ivy FI
ACS medicinal chemistry letters 20170525 7
Potent and selective κ opioid receptor antagonists have been derived from the <i>N</i>-substituted <i>trans</i>-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of pure opioid receptor antagonists. In order to determine if the 3-hydroxyphenyl and/or the piperidine amino groups are required for obtaining the pure opioid antagonists, (3<i>R</i>)-7-hydroxy-<i>N</i>-[(1<i>S</i>)-2-methyl-1-(piperidine-1-ylmethyl)propyl]-1,2,3,4-tetrahydroiosquinoline-3-carboxamide (<b>1</b>), which does not have a 4 ...[more]