Ontology highlight
ABSTRACT:
SUBMITTER: Page S
PROVIDER: S-EPMC7145521 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Page Sarah S Mavrikaki Maria M MM Lintz Tania T Puttick Daniel D Roberts Edward E Rosen Hugh H Carroll F Ivy FI Carlezon William A WA Chartoff Elena H EH
The international journal of neuropsychopharmacology 20191101 11
<h4>Background</h4>New treatments for stress-related disorders including depression, anxiety, and substance use disorder are greatly needed. Kappa opioid receptors are expressed in the central nervous system, including areas implicated in analgesia and affective state. Although kappa opioid receptor agonists share the antinociceptive effects of mu opioid receptor agonists, they also tend to produce negative affective states. In contrast, selective kappa opioid receptor antagonists have antidepre ...[more]