Ontology highlight
ABSTRACT:
SUBMITTER: Wang P
PROVIDER: S-EPMC5512281 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20160719 29
Here we report the development of a versatile 3-acetylamino-2-hydroxypyridine class of ligands that promote meta-C-H arylation of anilines, heterocyclic aromatic amines, phenols, and 2-benzyl heterocycles using norbornene as a transient mediator. More than 120 examples are presented, demonstrating this ligand scaffold enables a wide substrate and coupling partner scope. Meta-C-H arylation with heterocyclic aryl iodides as coupling partners is also realized for the first time using this ligand. T ...[more]