Ontology highlight
ABSTRACT:
SUBMITTER: Gemoets HPL
PROVIDER: S-EPMC5488246 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20170522 25
Described herein is an effective and practical modular flow design for the meta-selective C-H arylation of anilines. The design consists of four continuous-flow modules (i.e., diaryliodonium salt synthesis, meta-selective C-H arylation, inline copper extraction, and aniline deprotection) which can be operated either individually or consecutively to provide direct access to meta-arylated anilines. With a total residence time of 1 hour, the desired product could be obtained in high yield and excel ...[more]