Ontology highlight
ABSTRACT:
SUBMITTER: Key CC
PROVIDER: S-EPMC5512440 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Cell reports 20170601 10
Plasma membrane (PM) free cholesterol (FC) is emerging as an important modulator of signal transduction. Here, we show that hepatocyte-specific knockout (HSKO) of the cellular FC exporter, ATP-binding cassette transporter A1 (ABCA1), leads to decreased PM FC content and defective trafficking of lysosomal FC to the PM. Compared with controls, chow-fed HSKO mice had reduced hepatic (1) insulin-stimulated Akt phosphorylation, (2) activation of the lipogenic transcription factor Sterol Regulatory El ...[more]