Ontology highlight
ABSTRACT:
SUBMITTER: Funai K
PROVIDER: S-EPMC3582136 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Funai Katsuhiko K Song Haowei H Yin Li L Lodhi Irfan J IJ Wei Xiaochao X Yoshino Jun J Coleman Trey T Semenkovich Clay F CF
The Journal of clinical investigation 20130208 3
Exogenous dietary fat can induce obesity and promote diabetes, but endogenous fat production is not thought to affect skeletal muscle insulin resistance, an antecedent of metabolic disease. Unexpectedly, the lipogenic enzyme fatty acid synthase (FAS) was increased in the skeletal muscle of mice with diet-induced obesity and insulin resistance. Skeletal muscle-specific inactivation of FAS protected mice from insulin resistance without altering adiposity, specific inflammatory mediators of insulin ...[more]