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Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon?.


ABSTRACT: The gut microbiota of breast-fed and formula-fed infants differ significantly, as do the risks for allergies, gut dysfunction, and upper respiratory tract infections. The connections between breast milk, various formulas, and the profiles of gut bacteria to these childhood illnesses, as well as the mechanisms underlying the effects, are not well understood.We investigated distal colon microbiota by 16S RNA amplicon sequencing, morphology by histomorphometry, immune response by cytokine expression, and tryptophan metabolism in a pig model in which piglets were sow-fed, or fed soy or dairy milk-based formula from postnatal day (PND) 2 to 21.Formula feeding significantly (p?

SUBMITTER: Saraf MK 

PROVIDER: S-EPMC5513086 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon.

Saraf Manish Kumar MK   Piccolo Brian D BD   Bowlin Anne K AK   Mercer Kelly E KE   LeRoith Tanya T   Chintapalli Sree V SV   Shankar Kartik K   Badger Thomas M TM   Yeruva Laxmi L  

Microbiome 20170714 1


<h4>Background</h4>The gut microbiota of breast-fed and formula-fed infants differ significantly, as do the risks for allergies, gut dysfunction, and upper respiratory tract infections. The connections between breast milk, various formulas, and the profiles of gut bacteria to these childhood illnesses, as well as the mechanisms underlying the effects, are not well understood.<h4>Methods</h4>We investigated distal colon microbiota by 16S RNA amplicon sequencing, morphology by histomorphometry, im  ...[more]

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